Bioinformatics study and expression changes of the ACE gene in rats under the influence of motor stimuli and sports performance
Keywords:
Exercise, angiotensin-II, protein kinase, ACE, Gene ExpressionAbstract
Abstract
Exercise is the most important factor in preventing mental and physical diseases. Sports activities ensure the health of vital organs of the body, such as the heart and brain. In recent years, researchers have carefully examined the factors affecting changes in the body's metabolism following sports activities. Many of these factors cause major hormonal and genetic changes in the body. One of the genes whose expression changes are always affected by sport activities is the ACE gene. Changes in the expression level of this gene have significant effects on blood pressure and heart health. In general, the ACE gene is a protein kinase that causes the release of large amounts of angiotensin-II in tissues. Increased production of angiotensin-II leads to muscle contraction and increased blood pressure, which in turn increases the risk of heart attack. Also, increased expression of the ACE gene through increased angiotensin-II plays a major role in blood electrolyte balance. In addition, this gene plays an effective role in stimulating the hormone aldosterone, ultimately leading to the regulation of intracellular fluids in the body. This study showed that the expression level of the ACE gene in rats exposed to motor activity increased after 12 hours and decreased after 24 hours. Also, the expression level of the ACE gene in the small intestine and duodenum was higher than in other organs, while this level was at its lowest in the cerebral cortex and skin. In general, these results showed that endurance activities play an effective role in reducing the expression level of the ACE gene. The bioinformatics analysis of this study also showed that there are a total of 14 protein sequences with more than 50% similarity in humans that contain the Lisinopril ligand, while these ligands play an effective role in the electrolyte balance of the ACE protein. In general, this study showed that there is a relatively active relationship between muscular and endurance sports such as running and ACE gene activity. It is hoped that this research, along with other related research, will lead to a greater understanding and identification of the mechanisms of the effect of these genes on energy metabolism and the level of oxygen consumption of cells during sports activities.
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Copyright (c) 2025 Alireza Mirzaei, Sepehr Kahrizi (Author)
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