Advancing Human Performance: Genomic Innovations and Ethical Imperatives in Sports Science

Authors

    Danial Kahrizi * Biotechnology Department, Tarbiat Modares University, Tehran Iran dkahrizi@modares.ac.ir
https://doi.org/10.61838/kman.intjssh.8.4.5

Keywords:

Genomics, Gene Expression, Next-Generation Sequencing (NGS), Polygenic Risk Scores (PRS), Athletic Performance

Abstract

The rapid convergence of genomic technologies and sports science is redefining the boundaries of human athletic potential. As a researcher at the intersection of molecular biology and sports medicine, I applaud your journal’s commitment to this transformative field and wish to expand upon critical developments in gene expression regulation, CRISPR-Cas9 applications, and next-generation sequencing (NGS) that demand scholarly attention and ethical scrutiny.

Downloads

Download data is not yet available.

References

1. Bulgay C, Cepicka L, Dalip M, Yıldırım S, Ceylan HI, Yılmaz Ö, et al. The relationships between ACTN3 rs1815739 and PPARA-α rs4253778 gene polymorphisms and athletic performance characteristics in professional soccer players. BMC sports science, medicine & rehabilitation. 2023;15(1):121. [PMID: 37749582] [PMCID: PMC10518950] [DOI]

2. Earhart ML, Blanchard TS, Strowbridge N, Sheena R, McMaster C, Staples B, et al. Heatwave resilience of juvenile white sturgeon is associated with epigenetic and transcriptional alterations. Sci Rep. 2023;13(1):15451. [PMID: 37723229] [PMCID: PMC10507091] [DOI]

3. Li J, Zhang S, Li C, Zhang X, Shan Y, Zhang Z, et al. Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis. Sci Rep. 2024;14(1):21154. [PMID: 39256490] [PMCID: PMC11387812] [DOI]

4. Chae SY, Jeong E, Kang S, Yim Y, Kim JS, Min DH. Rationally designed nanoparticle delivery of Cas9 ribonucleoprotein for effective gene editing. Journal of controlled release : official journal of the Controlled Release Society. 2022;345:108-19. [PMID: 35247491] [DOI]

5. Bojarczuk A. Ethical Aspects of Human Genome Research in Sports-A Narrative Review. Genes (Basel). 2024;15(9). [PMID: 39336807] [PMCID: PMC11430849] [DOI]

6. Ren X, Shi Y, Xiao B, Su X, Shi H, He G, et al. Gene Doping Detection From the Perspective of 3D Genome. Drug testing and analysis. 2025. [PMID: 39757126] [DOI]

7. Xue Y, Shang L. Governance of Heritable Human Gene Editing World-Wide and Beyond. Int J Environ Res Public Health. 2022;19(11). [PMID: 35682323] [PMCID: PMC9180052] [DOI]

8. Chikowore T, Läll K, Micklesfield LK, Lombard Z, Goedecke JH, Fatumo S, et al. Variability of polygenic prediction for body mass index in Africa. Genome medicine. 2024;16(1):74. [PMID: 38816834] [PMCID: PMC11140909] [DOI]

9. Suwinski P, Ong C, Ling MHT, Poh YM, Khan AM, Ong HS. Advancing Personalized Medicine Through the Application of Whole Exome Sequencing and Big Data Analytics. Front Genet. 2019;10:49. [PMID: 30809243] [PMCID: PMC6379253] [DOI]

10. Badr J, Motulsky A, Denis JL. Digital health technologies and inequalities: A scoping review of potential impacts and policy recommendations. Health policy (Amsterdam, Netherlands). 2024;146:105122. [PMID: 38986333] [DOI]

11. Magee P, Ienca M, Farahany N. Beyond neural data: Cognitive biometrics and mental privacy. Neuron. 2024;112(18):3017-28. [PMID: 39326392] [DOI]

Additional Files

Published

2025-10-01

How to Cite

Kahrizi, D. (2025). Advancing Human Performance: Genomic Innovations and Ethical Imperatives in Sports Science. International Journal of Sport Studies for Health, 8(4), 1-3. https://doi.org/10.61838/kman.intjssh.8.4.5