Advancing Human Performance: Genomic Innovations and Ethical Imperatives in Sports Science
Keywords:
Genomics, Gene Expression, Next-Generation Sequencing (NGS), Polygenic Risk Scores (PRS), Athletic PerformanceAbstract
The rapid convergence of genomic technologies and sports science is redefining the boundaries of human athletic potential. As a researcher at the intersection of molecular biology and sports medicine, I applaud your journal’s commitment to this transformative field and wish to expand upon critical developments in gene expression regulation, CRISPR-Cas9 applications, and next-generation sequencing (NGS) that demand scholarly attention and ethical scrutiny.
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1. Bulgay C, Cepicka L, Dalip M, Yıldırım S, Ceylan HI, Yılmaz Ö, et al. The relationships between ACTN3 rs1815739 and PPARA-α rs4253778 gene polymorphisms and athletic performance characteristics in professional soccer players. BMC sports science, medicine & rehabilitation. 2023;15(1):121. [PMID: 37749582] [PMCID: PMC10518950] [DOI]
2. Earhart ML, Blanchard TS, Strowbridge N, Sheena R, McMaster C, Staples B, et al. Heatwave resilience of juvenile white sturgeon is associated with epigenetic and transcriptional alterations. Sci Rep. 2023;13(1):15451. [PMID: 37723229] [PMCID: PMC10507091] [DOI]
3. Li J, Zhang S, Li C, Zhang X, Shan Y, Zhang Z, et al. Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis. Sci Rep. 2024;14(1):21154. [PMID: 39256490] [PMCID: PMC11387812] [DOI]
4. Chae SY, Jeong E, Kang S, Yim Y, Kim JS, Min DH. Rationally designed nanoparticle delivery of Cas9 ribonucleoprotein for effective gene editing. Journal of controlled release : official journal of the Controlled Release Society. 2022;345:108-19. [PMID: 35247491] [DOI]
5. Bojarczuk A. Ethical Aspects of Human Genome Research in Sports-A Narrative Review. Genes (Basel). 2024;15(9). [PMID: 39336807] [PMCID: PMC11430849] [DOI]
6. Ren X, Shi Y, Xiao B, Su X, Shi H, He G, et al. Gene Doping Detection From the Perspective of 3D Genome. Drug testing and analysis. 2025. [PMID: 39757126] [DOI]
7. Xue Y, Shang L. Governance of Heritable Human Gene Editing World-Wide and Beyond. Int J Environ Res Public Health. 2022;19(11). [PMID: 35682323] [PMCID: PMC9180052] [DOI]
8. Chikowore T, Läll K, Micklesfield LK, Lombard Z, Goedecke JH, Fatumo S, et al. Variability of polygenic prediction for body mass index in Africa. Genome medicine. 2024;16(1):74. [PMID: 38816834] [PMCID: PMC11140909] [DOI]
9. Suwinski P, Ong C, Ling MHT, Poh YM, Khan AM, Ong HS. Advancing Personalized Medicine Through the Application of Whole Exome Sequencing and Big Data Analytics. Front Genet. 2019;10:49. [PMID: 30809243] [PMCID: PMC6379253] [DOI]
10. Badr J, Motulsky A, Denis JL. Digital health technologies and inequalities: A scoping review of potential impacts and policy recommendations. Health policy (Amsterdam, Netherlands). 2024;146:105122. [PMID: 38986333] [DOI]
11. Magee P, Ienca M, Farahany N. Beyond neural data: Cognitive biometrics and mental privacy. Neuron. 2024;112(18):3017-28. [PMID: 39326392] [DOI]
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Copyright (c) 2025 Danial Kahrizi (Author)

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