KMAN Publication Inc. Quality of Life and Health Sciences 1 Serial Number 1 2025 07 01 Experiences of Fatigue, Emotional Distress, and Daily Functioning Among Patients With Multiple Sclerosis: A Qualitative Study of Health-Related Quality of Life Experiences of Fatigue, Emotional Distress, and Daily Functioning Among Patients With Multiple Sclerosis: A Qualitative Study of Health-Related Quality of Life 1 16 10.61838/c589zy62 EN Journal Article 2025 03 14 <table> <tbody> <tr> <td> <p>Objective: This study aimed to explore the lived experiences of fatigue, emotional distress, and daily functioning among patients with multiple sclerosis in Canada and to understand how these experiences shape their health-related quality of life.</p> <p><strong>Methods and Materials:</strong> This qualitative phenomenological study was conducted among 26 adult patients with a confirmed diagnosis of multiple sclerosis who were recruited from neurology clinics, community-based multiple sclerosis organizations, and patient support groups in Toronto, Ontario, Canada. Participants were selected through purposeful sampling with maximum variation in age, gender, disease duration, disease type, occupational status, and functional limitation. Data were collected using a demographic and clinical information form, semi-structured individual interviews, audio recordings, and researcher field notes. Interviews focused on patients’ experiences of fatigue, emotional distress, functional limitations, coping strategies, social participation, family and occupational roles, and perceived changes in health-related quality of life. Data collection continued until thematic saturation was achieved. Interviews were transcribed verbatim and analyzed using inductive thematic analysis. Credibility and trustworthiness were strengthened through peer debriefing, reflexive memo writing, comparison of coding decisions, an audit trail, and participant feedback on interpreted themes.</p> <p><strong>Findings:</strong> Thematic analysis revealed six major themes: fatigue as a dominant and unpredictable burden, emotional distress and psychological vulnerability, disruption of daily functioning and role performance, coping and reconstruction of normal life, social understanding and stigma, and health-related quality of life as a balance between limitation and control. Fatigue emerged as the most pervasive experience and affected physical activity, cognitive functioning, emotional regulation, employment, and social participation. Emotional distress was mainly associated with anxiety about progression, grief for the previous self, fear of dependency, irritability, and uncertainty about the future. Daily functioning was disrupted through limitations in work, household tasks, mobility, family roles, and social engagement. Protective factors included pacing, acceptance, social support, accessibility, and preservation of meaningful activities.</p> <p><strong>Conclusion:</strong> Health-related quality of life among patients with multiple sclerosis is shaped by the dynamic interaction of fatigue, emotional distress, functional limitation, coping capacity, and social context. Patient-centered care should address both visible and invisible symptoms and support autonomy, emotional balance, meaningful participation, and daily functioning.</p> </td> </tr> </tbody> </table> https://www.journals.kmanpub.com/index.php/qlhs/article/download/5764/10918