KMAN Publication Inc. (KMANPUB) Journal of Adolescent and Youth Psychological Studies (JAYPS) 2981-2526 7 Serial Number 43 2026 03 10 Identifying Novel Endophenotypes of Adolescent Insomnia and their Association with Emotional Dysregulation Identifying Novel Endophenotypes of Adolescent Insomnia and their Association with Emotional Dysregulation 1 10 10.61838/kman.jayps.1051 EN Journal Article 2025 11 10 <table> <tbody> <tr> <td> <p><strong>Objective:</strong> This study aimed to identify unobservable endophenotypes of adolescent insomnia utilizing latent variable modeling and to evaluate their differential associations with specific facets of emotional dysregulation.</p> <p><strong>Methods and Materials:</strong> A cross-sectional design was employed, encompassing a community sample of adolescents in Egypt. Sleep parameters were rigorously assessed using continuous objective actigraphy worn in the home environment, paired with the subjective self-report Insomnia Severity Index. Emotional dysregulation was quantified using the multidimensional Difficulties in Emotion Regulation Scale. To uncover hidden sub-populations, Latent Profile Analysis was conducted in R using the combined objective and subjective sleep metrics. Subsequently, a Multivariate Analysis of Covariance was utilized to determine how the derived sleep profiles differentially predicted impairments across the various emotional dysregulation subscales, controlling for demographic covariates.</p> <p><strong>Findings:</strong> The Latent Profile Analysis successfully identified distinct insomnia endophenotypes within the adolescent sample: Normative Sleepers, Sleep Onset Delay, and High Fragmentation. The multivariate analyses revealed highly specific associations between these profiles and emotional functioning. Adolescents classified within the Sleep Onset Delay profile demonstrated specialized emotional deficits, specifically characterized by a lack of emotional clarity and severe difficulties engaging in goal-directed behaviors ( ). Conversely, the High Fragmentation profile—marked by extensive wake after sleep onset and reduced total sleep time—was associated with the most severe global impairments in emotion regulation, manifesting primarily as profound deficits in impulse control and a high nonacceptance of emotional responses ( ).</p> <p><strong>Conclusion:</strong> Adolescent insomnia is not a monolithic disorder but a heterogeneous construct comprising distinct endophenotypes linked to specific emotional vulnerabilities. Precision behavioral medicine that tailors interventions to exact sleep architectural disruptions may significantly optimize clinical outcomes and mitigate psychopathological risks.</p> </td> </tr> </tbody> </table> https://www.journals.kmanpub.com/index.php/jayps/article/download/1051/9332