KMAN Publication Inc. (KMANPUB) Health Nexus In Press 2026 10 01 Independent and Interactive Effects of Combined Aerobic–Resistance Training and Coenzyme Q10 Supplementation on Amyloidogenic Pathway Markers and IDE-Dependent Amyloid Clearance in the Hippocampus of Male Wistar Rats With Amyloid-β-Induced Alzheimer-Like Pathology Independent and Interactive Effects of Combined Aerobic–Resistance Training and Coenzyme Q10 Supplementation on Amyloidogenic Pathway Markers and IDE-Dependent Amyloid Clearance in the Hippocampus of Male Wistar Rats With Amyloid-β-Induced Alzheimer-Like Pathology 1 12 10.61838/ EN Journal Article 2026 04 10 <p>Alzheimer-like pathology is associated with increased amyloid-β production and impaired peptide clearance. This study investigated the independent and interactive effects of combined aerobic-resistance training and coenzyme Q10 supplementation on hippocampal markers of amyloidogenic processing and insulin-degrading enzyme (IDE)-dependent clearance. Forty-eight male Wistar rats were allocated to six groups (n = 8): healthy control, sham, Alzheimer-like pathology, Alzheimer-like pathology plus combined training, Alzheimer-like pathology plus coenzyme Q10, and Alzheimer-like pathology plus combined training and coenzyme Q10. Alzheimer-like pathology was induced by intracerebroventricular Aβ1-42 administration. The combined training protocol and a diet containing 0.4% coenzyme Q10 were applied for 12 weeks. Hippocampal APP, BACE1, PSEN1, and IDE gene expression was measured by real-time PCR; Aβ42 concentration was measured by ELISA; and IDE activity was determined enzymatically. One-way ANOVA with Tukey testing and 2 × 2 two-way ANOVA were used. Model induction significantly increased APP, BACE1, PSEN1, and Aβ42 and reduced IDE expression and activity. Training and coenzyme Q10 each significantly attenuated all alterations. The combined-intervention group showed the most favorable means across all outcomes. Significant training-by-supplementation interactions were observed for BACE1 and Aβ42, but not for APP, PSEN1, IDE expression, or IDE activity. Combined aerobic-resistance training and coenzyme Q10 supplementation improved the balance between markers related to amyloid production and IDE-dependent clearance in this rat model. The findings are limited to hippocampal molecular outcomes in an experimentally induced Alzheimer-like condition and require confirmation using protein-level, histological, cognitive, and translational assessments.</p> https://www.journals.kmanpub.com/index.php/Health-Nexus/article/download/5837/11188